Research, news and recognition
Scientific papers in plain language, explainers you can watch, and updates from the tocotrienol community. Search or filter by health area.
Why tocotrienols move faster in cell membranes
Serbinova E, Kagan V, Han D, Packer L
Free Radical Biology & Medicine · 1991
In membrane models, alpha-tocotrienol stopped lipid oxidation 40–60 times more efficiently than alpha-tocopherol.
Annatto tocotrienol and bone breakdown after menopause
Shen CL, Yang S, Tomison MD, et al.
Osteoporosis International · 2018
Postmenopausal women with low bone density took annatto tocotrienol or placebo for 12 weeks. Markers of bone breakdown and oxidative stress fell with tocotrienol.
Delta-tocotrienol in non-alcoholic fatty liver disease
Pervez MA, Khan DA, Ijaz A, Khan S
Turkish Journal of Gastroenterology · 2018
Patients with NAFLD took delta-tocotrienol or placebo. The study reported improvements in liver enzymes, inflammation and oxidative-stress markers, and in the fatty liver index.
Tocotrienols and fatty liver on ultrasound
Magosso E, Ansari MA, Gopalan Y, et al.
Nutrition Journal · 2013
Adults with ultrasound-diagnosed fatty liver took mixed tocotrienols or placebo for one year. More people in the tocotrienol group returned to a normal liver ultrasound.
How tocotrienols turn down cholesterol production
Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ
Journal of Biological Chemistry · 1993
Tocotrienols lowered levels of HMG-CoA reductase, the main cholesterol-making enzyme, by speeding up its breakdown.
Palm tocotrienols and brain white-matter lesions over two years
Gopalan Y, Shuaib IL, Magosso E, et al.
Stroke · 2014
Adults with existing white-matter lesions took mixed tocotrienols or placebo for two years; lesions grew less in the tocotrienol group.
Oral alpha-tocotrienol and stroke-related brain injury in rats
Khanna S, Roy S, Slivka A, et al.
Stroke · 2005
Rats given oral alpha-tocotrienol before an induced stroke showed smaller areas of brain damage than untreated animals.
Tocotrienol protects nerve cells from glutamate-triggered death
Sen CK, Khanna S, Roy S, Packer L
Journal of Biological Chemistry · 2000
Very low (nanomolar) amounts of alpha-tocotrienol stopped nerve cells dying after a glutamate challenge in the lab.