Bone Health

Human evidence: Emerging

Animal and early human studies suggest tocotrienols can slow bone breakdown, especially delta-rich annatto tocotrienol.

Evidence hierarchy

1

Mechanistic / in vitro studiesHow it may work

Tocotrienols reduce the activity of bone-resorbing cells (osteoclasts) in culture.

2

In vivo / animal studiesPreclinical evidence

In bone-loss models such as ovariectomised rats, tocotrienols helped preserve bone structure and strength.

3

Clinical studiesHuman evidence

A 12-week trial in postmenopausal women with osteopenia reported lower bone-resorption markers.

Shen CL et al., Osteoporosis International (2018) →

Evidence levels: In vitro explains how something may work; In vivo / animal tests it in a living body; Clinical (human) shows what happens in people. This page is educational and not medical advice.

From the Knowledge Hub

Clinical (human)Bone Health

Annatto tocotrienol and bone breakdown after menopause

Shen CL, Yang S, Tomison MD, et al.
Osteoporosis International · 2018

Postmenopausal women with low bone density took annatto tocotrienol or placebo for 12 weeks. Markers of bone breakdown and oxidative stress fell with tocotrienol.